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In CX3CR1 knockout mice, microglia retain contact with OPCs but exhibit reduced phagocytic activity, suggesting that CX3CR1 is crucial for engulfment rather than target detection alone (158, 185187)

Compound 2 , NADPH, and incubation time was varied as following: 1) TGR and 2 , no preincubation, 2) TGR, 2 , and NADPH, no preincubation, 3) TGR and 2 , 15 min preincubation, 4) TGR, 2 , and NADPH, 15 min preincubation, 5) TGR and NADPH followed by 15 min preincubation, 2 was added after 15 min preincubation, 6) TGR and 2 followed by 15 min preincubation, NADPH was added after 15 min preincubation

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Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN