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For instance, the fruit product dried prunes (138), conventionally categorized as a dietary supplement, has been shown to restore bone loss in OVX mice, as further studies have attributed this effect to polyphenols and carbohydrates, which are more explicitly identified as prebiotics

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however, the Leipzig score for ceruloplasmin, 24-h urinary copper, and K-F rings reached 3 or above, allowing for a diagnosis through genetic combination

In addition to these cellular components, the tumor microenvironment also includes non-cellular elements such as the extracellular matrix (ECM) and soluble factors such as chemokines, cytokines, growth factors and extracellular vesicles, all of which play a key role in tumor development and progression ( Fibroblasts contribute to tumor progression by secreting extracellular matrix components, growth factors and cytokines that promote tumor cell invasion, angiogenesis and immune modulation ( Tumor-associated immune cells can generally be classified into two categories: tumor-antagonistic immune cells and tumor-promoting immune cells