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This interaction forms an E3 ubiquitin ligase complex that binds to RUNX family transcription factor 2, promoting its ubiquitination and subsequent proteasomal degradation, thereby reducing arterial calcification (168)

doi: 10.3390/ijms25074047, 152

Oral cysteamine therapy has extended the time to kidney failure by approximately 7 years (to a mean of 16 years) and mitigates or prevents late complications of the disease

In this review, we integrate these emerging insights with foundational knowledge by outlining the biology of HSP70s, with particular emphasis on recent discoveries, such as new data on the substrate specificity and molecular dynamics of HSP70client interactions