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Indeed, most of the JmjC histone demethylases identified so far are capable of efficiently catalyzing demethylation of trimethylated lysines, and in most cases, they preferentially bind the trimethylated substrates [61, 62]

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Thus, the c-Met has become a major target for cancer therapy and its inhibition is currently being tested in the clinical trials [45]

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Here is the mechanism in practical terms

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10.1016/j.jare.2021.08.004 183 LiX.SunH.LiH.HuC.LuoY.ShiX.et al (2021)

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