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In addition, despite some studies on its toxicity, the FDA declared curcumin to be generally safe [118, 119]

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For people without deficiency, self-care should begin with basics that have stronger evidence: balanced meals, adequate protein, regular physical activity, hydration, sleep, and treatment of medical conditions that affect energy levels

23, 25 In contrast, no poor outcomes were identified to be independently associated with NBS in mut-MMA, possibly due to the fact that more mut-MMA patients develop symptoms before or during the process of NBS, a more severe condition with limited therapeutic effect, as shown in our study (Table 1)

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