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10.3390/biomedicines13020438 46 CuadradoA.RojoA

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The role of xanthine in resistance development is still not understood and more studies are needed to understand its role and the pathways associated with it, as it may be a potential marker for treatment resistance in different cancers, especially breast cancer

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GBM cells deliver immunosuppressive proteins such as CD73, CD39, programmed cell death ligand 1 (PD-L1), and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) into the local microenvironment through extracellular vesicles, leading to immune cell function impairment and tumor progression ( + T cell immunity and the immune evasion of GBM ( BMDMs and GBM cells collectively contribute to the immunosuppressive TME of GBM