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Stable Cdc50 loop-derived peptides were screened, and a myristylated AS15-based peptide showed activity at higher doses

Despite the lack of mortality or gross macroscopic injuries, there are measurable neurobehavioral deficits, diminished mitochondrial fission-fusion activities, bioenergetic failure, increased oxidative stress, diminished levels of mitophagy, acute increase in compensatory respiratory activity, as well as axonal myeline injury (Song et al., 2018c)

Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator

A successful needle insertion is indicated by a clear sense of penetration and a somewhat resistant retraction, with only air being aspirated back into the syringe

Wong J, Johnston B, Lee SS et al