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Dynamic balance of histone modification: SAMS-4 can enhance the modification of H3K4me3 in the absence of SAMS-1, and SAMS-1 is very important for heat shock response

Eventually, this phenomenon became known as the Jarisch-Herxheimer reaction. Over the years, patient communities have adopted a shortened version of the full name, calling them Herxheimer reactions, which Ill use moving forward, or herxes. The reaction tends to happen in people with spirochetal infections, such as Lyme disease, relapsing fever, and others, when theyre treated with antibiotics, according to a medical review in StatPearls

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They consist of microbial metabolites such as short-chain fatty acids (SCFAs), lipopolysaccharides, enzymes, and peptides (122)

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