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Clinical trials are needed to evaluate the safety and efficacy of targeted ferroptosis inhibitors in humans and to identify optimal dosages and delivery methods

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However, and paradoxically, long-term glutaminolysis activation during nutritional restriction induces an unbalanced activation of mTORC1 during nutrient deprivation and promotes apoptosis [92]

Second, peripheral vasospasm is believed to be present, causing increased peripheral resistance

9th Annual Oncology Update: Advances & Controversies