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Future research should focus on well-controlled, long-term clinical trials to assess both efficacy and safety

intracellular glutamate: ***p = 0.0002, *p = 0.0196

Our results about the effects of AFB1 on the antioxidant system are in accordance with a study that demonstrated a slight reduction of SOD, CAT, and GPx activities, and an increase in lipid peroxidation in chick kidney upon AFB1 treatment, even if at much higher concentration (1 mg/kg) and for a longer period (45 days) (41)

The roles of curcumin in regulating the tumor immunosuppressive microenvironment

AChE activity inhibition has been studied in various species, including Drosophila melanogaster exposed to dispersed blue-124 and black-9 textile dyes 57 , Electrophorus electricus subjected to bisphenol derivatives 52 ,and Periplaneta americana treated with 3-dimethylmaleic anhydride 16 .The binding energy (-7.0 kcal/mol), shows efficient binding of 4-NP with protein AChE, molecular docking study revealed that 4-NP was stabilized in the pocket of AChE mainly via interactions with hydrophobic residues i.e., Trp108, Tyr146, Leu152, Tyr155, ALa226, Phe315, Tyr355, Phe356, and Ile499.MD trajectory analysis showed that the AChE-4-NP complex remained stable throughout the 200 ns MD simulations in both runs