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Both in vitro glioma cell culture models and in vivo cell transplantation glioma models commonly used to test drugs and other anti-glioma therapies are predominantly composed of proliferating tumor cells, and therefore are not well suited to study quiescent glioma cells (LeBlanc et al, 2022

This is why combining them (CagriSema) produces greater weight loss than either alonethe mechanisms are complementary rather than redundant

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We further observed that DSF induced arginine catabolism as a probable compensatory response to deficient ATP production from cellular respiration