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Phase II study of cabozantinib in patients with progressive glioblastoma: subset analysis of patients naive to antiangiogenic therapy

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Pharmacol Ther (2014) 141(2):1509

This is achieved by mitigating PA uptake, promoting fatty acid oxidation, and encouraging lipid phagocytosis, all of which work in synergy to impede fat apoptosis

However, LVF triple therapy is not recommended as a first-line choice for most patients because resistance to LVF is increasing worldwide, but in areas of low LVF resistance and high CLR and MTZ resistance or unavailability of bismuth, this therapy can be used (OMorain et al