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It inhibits increases in [Ca 2+ ]i, blocks ROS production, and prevents the upregulation of IL-6, IL-8, ET-1, and VEGF in PASMCs, thereby reversing PVR in patients with HPH

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This combination therapy may inhibit tumor cell epithelial-mesenchymal transition via blocking CXCR2/TGF--mediated PI3K/Akt/GSK-3/Snail signaling pathway, suggesting potential for clinical trials in lung cancer patients [177]

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