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Protocol 4: nasal spray approach Goal: Needle-free administration with acceptable bioavailability trade-off Duration: 20 days active, then 4-6 months off Schedule: Days 1-20: 10-15 mg epitalon intranasally, divided into 2-3 daily doses Days 21-180: Off cycle Repeat 1-2 times per year Formulation: Reconstitute in saline with 3 percent DMSO for improved nasal absorption

Translational medicine Interference with indirect Coombs tests As CD38 is widely expressed on RBCs, both isatuximab and daratumumab can interfere with indirect Coombs tests used for blood compatibility testing [46, 47]

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