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doi: 10.1186/s40880-018-0288-x 57 BannaiS

Whereas autophagy can degrade large macromolecular complexes and even entire organelles, the UPS is characterized by exquisite substrate specificity, targeting only ubiquitinated proteins while preserving intact cellular structures

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In many regions, including Europe and North America, systemic sclerosis is the most common cause of connective tissue disease-related PAH, while systemic lupus erythematosus is more prevalent in Southeast Asia

While carb needs are relatively stable across the population (higher output or larger-bodied athletes need a bit more, but generally carb needs are tied to effort), hydration needs vary wildly