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Keywords: arsenic trioxide, acute promyelocytic leukemia, PML-RAR, drug resistance, drug metabolism Highlights 1.Arsenic trioxide achieves curative efficacy in acute promyelocytic leukemia by targeting and degrading the PML-RAR fusion oncoprotein

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When studied together, some reports describe amplified pulsatile growth hormone release, possibly indicating a synergistic interaction

Non-coding RNAs Non-coding RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are crucial regulators in the pathophysiology of DPN