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2.4 Statistical analysis We used R (version 4.1.2, R Foundation for Statistical Computing, Vienna, Austria) for data analysis and figure plotting

(2016, 2019) performed a randomized trial [96,97]

In a mouse model of cigarette smoking, oral yeast extract significantly reduced numbers of the pro-inflammatory cells, neutrophils, eosinophils, and lymphocytes in the lung alveoli, as well as the content of the inflammatory mediators COX-2 and NOS, which was attributed to the antioxidant and anti-inflammatory properties of yeast extract [110]