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Preclinical colitis models: KPV reduces mucosal inflammation in preclinical colitis models, with demonstrated reductions in TNF-, IL-6, and other pro-inflammatory markers

Gastrointestinal symptoms (more common with oral preparations): Mild nausea or upset stomach Diarrhoea (typically with very high doses) Other effects: Headache, particularly when treatment is first initiated Dizziness or light-headedness Skin reactions such as mild rash or itching Temporary reddish discolouration of urine (chromaturia) after hydroxocobalamin injections, which is harmless It is important to note that many symptoms attributed to B12 supplementation may actually represent the body's response to correcting a deficiency

The inhibitory effect on TNF- secretion was dependent on the percentage of modified bases in the RNA [4]

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