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Any alcohol use, including light drinking, has been independently linked to an increased risk of HCC in MASLD patients [282,286,287]

After applying 1:1:1:1 IPTW, the incidence of HCC in BSV users (n=7 of 591, 3.8 per 1000 PYs) was similar to that in TAF users (n=17 of 713, 8.6 per 1000 PYs, adjusted HR [aHR] 2.324, 95% CI 0.8946.043), however, significantly lower than in ETV (n=32 of 706, 12.4 per 1000 PYs, aHR 2.795 (95% CI 1.1386.866, E-value 5.035) and TDF users (n=34 of 674, 14.6 per 1000 PYs, aHR 3.322 (95% CI 1.3348.274, E- value 6.099)

By univariate analysis, LTSs were more often females, younger, received younger D-graft, more commonly transplanted for HBV+HDV and ALD

Biomark Res 6:14 Sripada A et al (2021) Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases

Nevertheless, our data open a new direction for the design of a therapeutic strategy that could be applied postnatally and might help to combat the brain-related phenotype of 22q11.2DS