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In Part I we discussed the potential role of the COMT gene in disorders such as schizophrenia, bipolar disorder and possibly ME/CFS and that the RORA gene may help explain the gender imbalance in ASD

This is supported by reductions in neuroinflammatory mediators, including TNF-, IL-1, and iNOS, alongside the downregulation of TLR4 transcriptional regulators, such as p-c-Jun and PU.1 [171]