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Shikonin (SHI) is a naphthoquinone compound extracted from the root of Lithospermum erythrorhizon Siebold and Zucc, which has been widely used in Asia, and is currently believed to have less obvious side effects, and has anti-tumor (Wang et al., 2024), anti-viral (Watson et al., 2023) effects

Neuron 68 , 99112 (2010)

These PLA2G2A + meCAFs significantly inhibit the antitumor function of CD8 + T cells by secreting PLA2G2A protein, thereby forming an immunosuppressive microenvironment

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Andrew: One amino acid- Craig: Correct