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Moreover, the downregulation or loss-of-function of the PTEN gene leads to the accumulation of phosphatidylinositol-3,4,5-triphosphate, subsequently enhancing phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) and ERK activity, increasing mitogen signaling and/or decreasing apoptosis, and ultimately leading to liver fibrosis (Yang et al., 2015)

Parkin: a multifaceted ubiquitin ligase

MEK blockade converts AML differentiating response to retinoic acid (RA) into extensive apoptosis

Aromatic L-amino acid decarboxylase

Patients with Type 2 diabetes mellitus have an exaggerated brachial and central blood pressure response to exercise: relation to left ventricular hypertrophy