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Furthermore, they regulate the transcription of pro- and anti-inflammatory proteins, reduce hs-CRP, inhibit microglia activation, suppress ICAM-1, VCAM-1, and PGE2, decrease iNOS mRNA, and regulate heme oxygenase-1 mRNA expression (Figure 4)

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Regulatory phenomena in the glutathione peroxidase superfamily

Am J Physiol Heart Circ Physiol 285:H1385H1395 Lefer DJ, Scalia R, Campbell B, Nossuli T, Hayward R, Salamon M, Grayson J, Lefer AM (1997) Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats