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Based on the data available in 2015, EFSA did not identify any known health risks associated with the use of dietary supplements, so no maximum dose or maximum daily intake, also known as a tolerable upper intake, was set (EFSA, 2015)

1,2,6 Skin hyperpigmentation, glossitis, and infertility have also been reported

Pregnancy and breastfeeding require individualized risk-benefit assessment

Of note, whereas drug adverse effects may emerge early because of the sudden exposure of the body to a new substance, adverse effects tend to be clearly present only when a critical threshold, usually related to blood level, is reached

Hiya, I am very sensitive to pain so, after quick insertion of needle, I inject very slowly, a little at a time, and stop as soon as it hurts, rest a few seconds, then resume