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Lower glutathione levels result in the accumulation of certain toxins that were previously kept in check

Stanhope KJ, Mirza NR, Bickerdike MJ, Bright JL, Harrington NR, Hesselink MB et al (2001)

The term thiamine deficiency disorders (TDDs) was created to describe the symptoms resulting from thiamine deficiency at different stages of life [26]

Vitamin C promotes oligodendrocytes generation and remyelination

This linkage implies that the same may be true for NADPHthat diminished TCA cycle activity might stimulate NADPH production by 1C metabolismthough the enzymes in 1C metabolism that produce NADH and NADPH rely on the same folate derivatives, and it remains unclear whether the cell would prioritize reducing NAD+ over NADP+