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While not appropriate for acute severe pain requiring immediate analgesia, peptides may reduce chronic pain by addressing underlying pathology that perpetuates pain signaling

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More specifically, RCTs with immunoadsorption, rilzabrutinib, and efgartigimod in pemphigus, as well as dupilumab, benralizumab, mepolizumab, avdoralimab, and efgartigimod in bullous pemphigoid are summarized