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Among the mechanisms impaired by environmental stress are the cytokine-receptor interaction pathway, toll-like receptor signaling pathways, and the production of excessive reactive oxygen species (ROS) in response to multiple impaired immune pathways (Hofmann et al ., 2020)

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In this regard, silibinin has been found to be a potentially effective substance in the modulation of mitochondrial dysfunction and the consequence formation of reactive oxygen/nitrogen species that are included in the initiation and progression of chronic liver disease, age-related neurodegenerative disorders, and other chronic diseases [220, 221]

doi: 10.3390/antiox12020406 75 DhowlagharNDhananiTPillaiSSPatilBS