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Preclinical and clinical studies have indicated that GLP-1 receptor agonists can ameliorate kidney function by reducing inflammation, oxidative stress, and fibrosis, which are key contributors to diabetic nephropathy

10.1016/B978-0-12-811410-0.00045-3 535

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In clinical settings, trials harnessing active targeting strategies show promise

For example, TLR4 activates the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) signaling pathway through the recognition of lipopolysaccharides (LPS), promoting the release of pro-inflammatory cytokines and exacerbating intestinal inflammation [8]