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(3) The use of suboptimal dosing regimens in clinical trials could give false-negative results

So, over the last two decades, acetylcholinesterase (AChE) has been the focus of intensive pharmaceutical research, resulting in the development of several drugs currently in clinical use for the treatment of AD, with AChE inhibitors constituting many drugs approved by the FDA for the disease [6, 7]

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Leffers, N

It is needed to produce methylfolate, which recycles homocysteine, produces SAMe and recycles biopterin, all extremely important nutrients in the body