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The PDX dataset (Neuroblastoma COJEC in vivoPDX123) and PDX-derived organoids dataset (Neuroblastoma COJEC_PDX3 organoids) from previous work 12 and from the current project for organoids (Neuroblastoma Auranofin Comb PDX1andPDX3R_org) and in vivo (NB_Aur-COJEC_PDX1_invivo) are publicly available in the R2 Genomics platform ( Analysis and visualization of heatmaps and differentially expressed genes (DEGs) were done using R2, FDR 100 for cell death

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As the OD value of the standard curve may vary according to the conditions of the actual assay performance (e.g operator, pipetting technique or temperature effects), so the standard curve and data are provided as below for reference only

Benet, Leslie Z, Kroetz, Deanna L

In melanocytes 4-HNE, through adduct formation, alters protein function, contributing to oxidative stress-induced cellular dysfunction, which mainly concerns on the functioning of cellular antioxidant system, acceleration of protein degradation, inhibition of melanocyte proliferation, photoaging processes, but also disruption of the intercellular interactions between melanocytes and keratinocytes 101,102,103