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Biomaterials 59 , 160171 (2015)

Chronic pain can have multiple drivers, including nerve irritation, metabolic inflammation, and biomechanical compensation

The composition according to claims 1 -1 144, wherein the composition comprises one or more pharmamers immobilised onto a solid or semi-solid support such as particles, beads, biodegradable particles, sheets, gels, filters, membranes, fibres, capillaries, needles, microtitre strips, tubes, plates or wells, combs, pipette tips, micro arrays, and chips

Future research directions should include: optimizing combination therapies (Mai et al., 2025)

Most GI side effects peak during dose escalation phases and improve within 2 to 4 weeks at a stable dose