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(mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells

10.1155/2019/7850324 64 YuanL.LiuS.BaiX.GaoY.LiuG.WangX.et al (2016)

What else can Uremia be

Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon

ABHD11 loss resulted in increased HIF-1 levels and decreased 5hmC, similarly to ML226 inhibition, whereas GCDH depletion only decreased 5hmC levels (Fig