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There are other problems associated with traditional antibiotic discovery methods, including the search for amplification of known chemical scaffolds, low access to new chemical varieties, and essentially a focus on individual bacterial cells, which may not be effective concerning the bacterial preference of forming colonies and even biofilms with different bacterial species [56]

Halevas E, Nday CM, Salifoglou A (2016) Hybrid catechin silica nanoparticle influence on Cu(II) toxicity and morphological lesions in primary neuronal cells

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