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When the PI3K/AKT/mTOR survival pathway was activated by radiotherapy, PF-04691502 facilitated the efficacy of radiotherapy by inhibiting phosphorylation of effectors in the pathway in HNSCC xenografts, similar to other inhibitors in the PI3K/AKT/mTOR pathway

These findings underscore the potential therapeutic relevance of GHSs in preserving or enhancing lean body mass