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Innov Food Sci Emerg Technol 77(1):102989 Zhou W, Li J, Wang X, Liu L, Li Y, Song R, Zhang M, Li X (2023) Research progress on extraction, separation, and purification methods of plant essential oils

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(2) ROS activates NF-B and MAPK signaling pathways, upregulating the expression of MMPs (MMP-13, MMP-3) and inflammatory factors (IL-1, TNF- ), thereby accelerating the degradation of type II collagen (Col-II) and proteoglycans