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The method of any one of 21

Nevertheless, no inhibitor has yet reached phase I clinical trials and further efforts are needed to circumvent all obstacles related to absorption, metabolism and various issues on pharmacokinetics in order to eventually achieve orally bioavailable drug candidates acting as cognitive enhancers in vivo

In hypoxic conditions, HIF-1 acts as the main mediator of a series of in vivo pathophysiological responses, including angiogenesis, cell proliferation, and transcriptional induction of survival genes (30)