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Metformin as a therapeutic target in endometrial cancers

For instance, in a rat model of Lipopolysaccharide (LPS)-induced renal dysfunction, EC treatment significantly reduced NF-B p65 phosphorylation at Ser536 and lowered the nuclear-to-cytoplasmic p65 ratio, while preventing IB degradation, indicating its capacity to suppress NF-B activation and mitigate renal inflammation (Prince et al., 2017)