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Nonetheless, the aforementioned animal models, although extremely useful in investigating specific molecular mechanisms in the pathogenesis of ulcerative colitis, do not truly recapitulate disease as observed in patients, as IBD is a multifactorial disease and most clearly is not caused by a single mutation or defect in cellular or molecular pathways

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Whereas melatonin alone significantly reduced ex vivo production of IL-5 ( Figure 6J ) and IL-13 ( Figure 6K )

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Garca JA, Volt H, Venegas C et al (2015) Disruption of the NF-B/NLRP3 connection by melatonin requires retinoid-related orphan receptor-a and blocks the septic response in mice