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Weight loss failure on tirzepatide usually traces back to insufficient dose (need to escalate further), caloric intake still exceeding expenditure despite reduced appetite, metabolic adaptation, or underlying medical conditions like hypothyroidism or PCOS that require separate treatment

Commonly referenced guidance includes: Initial replacement Maintenance For maintenance, the BNF lists adult prophylaxis/maintenance dosing such as 1 mg intramuscularly every 23 months in appropriate cases

Scand J Haematol 1964;1:5-15

It also cannot protect anyone from the consequences of treating wine and cookies as a nightly wellness routine

The majority of participants were clinically obese adults, though one trial included healthy non-obese volunteers