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AIS: acute ischemic stroke Akt: protein kinase B BBB: blood-brain barrier Ea: electroacupuncture ECM: extracellular matrix GLP-1: glucagon-like peptide-1 GLP-1R: glucagon-like peptide-1 receptor HT: hemorrhagic transformation I/R: ischemia/reperfusion IGF-1: insulin-like growth factor-1 MCAO: middle cerebral artery occlusion miRNA: microRNA MMPs: matrix metalloproteinases MQC: mitochondrial quality control MSCs: mesenchymal stem cells NA-1: nerinetide NBP: 3- N -Butylphthalide NF-B: nuclear factor-kappa B NSCs: neural stem cells NVU: neurovascular unit PI3K: phosphoinositide 3-kinases STAIR: Stroke Treatment Academic Industry Roundtable TCM: traditional Chinese medicine TH: therapeutic hypothermia TIA: transient ischemic attack TLR4: Toll-like receptor 4 The authors would like to express their gratitude to the respective authors and scidraw.io for generously providing the original figure material in this article

Treatment time: 3060 minutes Minimal discomfort during insertion Relaxing environment while receiving treatment Medical oversight for safety and effectiveness Many clients use this time to unwind, recharge, or simply take a break from their day

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Comment: Many commenters shared their experience with the Vivistim System (paired vagus nerve stimulation) noting the effectiveness of the system to restore motor function in patients living with long term disabilities after having a stroke