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However, infants of vitamin B 12 -deficient breastfeeding mothers are vulnerable to B 12 deficiency from an early age.19 Maternal vitamin B 12 deficiency has been associated with increased risk of common pregnancy complications, including spontaneous abortion, low birth weight, intrauterine growth restriction and neural tube defects.2022 Children born to vitamin B 12 -deficient women are at increased risk for adverse health outcomes, including developmental abnormalities and anaemia.9 23 In a recent RCT in Bangalore, India, daily maternal vitamin B 12 supplementation (50 g/day) during pregnancy through 6 weeks postpartum substantially improved maternal vitamin B 12 status and increased breast milk and infant plasma vitamin B 12 concentrations.24 In this study, the proportion of children being born small for gestational age was lower in the vitamin B 12 group than in the placebo group (25% vs 34%)

Randomised clinical trials on vitamin B 12 in pregnancy are called for as concluded in a recent systematic review and meta-analysis.22 This trial will add to the knowledge on the potential beneficial effects of vitamin B 12 on pregnancy and perinatal outcomes.21 Our results can be used to inform both regional dietary guidelines for Nepalese and South Asian pregnant women

ACN, acetonitrile

Seiwerth et al

MOTS-c MOTS-c is a mitochondrial-derived peptide thats often discussed in wellness and longevity communities for its potential role in metabolic flexibility and cellular energy support