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As pointed out by the legendary immunologist Andrea Ablasser, such a universal sensing mechanism violates one of the most fundamental rules of the classical pattern recognition dogma, which is based on pathogen-specific structural patterns instructing self- versus nonself discrimination (123)

Hyper-inflammation (with CRS or cytokine storm) due to massive outburst of ROS, is a prominent clinical feature of COVID-19 145

[CrossRef] [PubMed] 27

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While previous reviews have focused on the overall role of ferroptosis in OA or orthopedic diseases, they often lack an in-depth analysis centered on GPX4 as the core inhibitory factor