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A key remaining question concerns the structural basis of the BPC157-FBXO22 interaction

doi:10.1056/NEJMoa2301972 Rosenstock J, Frias J, Jastreboff AM, et al

To diagnose fibromyalgia, the following are required: The presence of generalized pain, for which there is no other explanation, lasting at least three months and affecting at least four of five established body regions: the left upper, right upper, left lower, right lower, and axial (encompassing the head, neck, chest, and back) regions

Or, more likely, it could be that their effects are both interfering with that of BPC 157

1.52.0 g of synthetic vitamin B 12 saturates the IF-cobalamin ileal receptors, but other studies have shown higher absorption rates