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Octahedral metal coordination in the active site of glyoxalase I as evidenced by the properties of Co(II)-glyoxalase I

Gomez-Galan, M., De Bundel, D., Van Eeckhaut, A., Smolders, I

Maleimide-thiol reactions: thiol-selective maleimides enable precise, high-affinity covalent linkage to cysteine residues

ApoEs impact on glucose metabolism highlights its broader role in maintaining cellular energy balance, particularly in high-energy-demand tissues like the brain and the effect of its apoE4 isoform may contribute to energy deficits and increased oxidative stress, exacerbating neuronal vulnerability and promoting AD pathology