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In the acute phase of AD, Th2-mediated immune reactions initiate the release of pro-inflammatory cytokines, further perpetuating the inflammatory cascade (45)

Correspondingly, lactic acid also promotes tumour invasiveness through angiogenesis, immune evasion, and cell migration [186]

Despite their low surface density ( ~ 10 or fewer copies-per-cell), promising immunotherapies, primarily focused on KRAS G12D and KRAS G12V , are in development 9,10,12,13,14,15

SOD activity was examined using the SOD assay kitWST (DOJINDO LABORATORIES), according to the manufacturers instructions