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Molecules 26(9):2506 Seely D, Wu P, Fritz H, Kennedy DA, Tsui T, Seely AJ, Mills E (2012) Melatonin as adjuvant cancer care with and without chemotherapy: a systematic review and meta-analysis of randomized trials

Additionally, very few studies include comprehensive pharmacokinetic assessments or tissue distribution analyses, which are essential for determining whether therapeutically relevant concentrations are achieved in gastric tissue

93,94,95,96 Advancements in carrier technology and nucleic acid modification techniques have led to significant progress in overcoming these challenges, as exemplified by the first siRNA drug, patisiran (Onpattro), which has been approved for treating hereditary transthyretin-mediated amyloidosis by degrading mRNA encoding transthyretin (TTR)

Downstream analysis For heatmap visualizations, scaled SCTransformed values were used and the Complexheatmap package was used to generate visualization 100