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The group exposed to 72 h of NIR irradiation follows a similar trend of free Cisplatin but showed a slight reduction in viability (93 0.5%), (91 3.9%), probably due to delayed-onset toxicity

Aspray TJ, Prentice A, Cole TJ, et al

(Bottiglieri)

Figure 1 Iron metabolism At present, the exact molecular mechanism of iron overload leading to heart damage is mainly considered to be ferroptosis ( 2+ uniporter, which is essential in causing mitochondrial dysfunction and ferroptosis in cardiac iron overload ( Hepcidin, a peptide hormone originated from the liver, regulates iron absorption and distribution by suppressing the activity of transferrin ( The therapy targeting the hepcidin-transferrin axis has demonstrated initial potential, capable of effectively alleviating iron overload and ineffective erythropoiesis

The efficacy of zinc supplementation in treating AD remains controversial, with some studies suggesting no significant benefit, while others indicate potential therapeutic effects (182)