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H 2 O 2 induced a 1.73.0 fold increase in NRF2 target gene expression in ATM-wt tumors (n=4), whereas induction was significantly impaired in ATM-null CLLs (n=4) (Figure 1A)

When large amounts of iron are present in the body, ROS are generated, causing lipid peroxidation, damaging the lipid membranes, and causing cell death [105]

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After experimental pulmonary metastasis, IGF1R-deficient mice exhibited reduced tumor implantation in both LLC and melanoma models, as similarly observed upon heterotopic syngeneic transplantation