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Strictly speaking, IRI is a pathological state, with impacts that are not confined to the liver but also occur in other vital organs, including the heart and kidneys, leading to a series of adverse physiological reactions [194]

For example, while Piezo1 activation is known to facilitate vascular remodeling, its potential contribution to pathological calcium influx and tissue fibrosis under sustained activation has not been rigorously studied (136, 137)

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Mauri P, Benazzi L, Floh L et al (2003) Versatility of selenium catalysis in PHGPx unraveled by LC/ESI-MS/MS

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