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That is, mitochondrial signaling dictates macrophage polarization and function and is necessary for responses to activators of innate immune signaling

Expression of MRE11a DNA damage response proteindetermines the outcome of chemotherapy with the probable increase in chemoresistance [114]

PMID: 11 CanalesJ.Arenas-MA.MedinaJ.VidalE

The selective inhibitor compound 27 (IPN60090), which is currently in a first-in-class clinical trial, focuses on optimising physicochemical and pharmacokinetic properties, with a strong in vivo target engagement capability, and should strongly inhibit GLS in humans [152, 153]